「Concanavalin A」の編集履歴（バックアップ）一覧に戻る

Concanavalin A - (2011/10/15 (土) 19:07:51) のソース

Concanavalin A


Concanavalin A-induced hepatitis         NKT cells


A recent (2009) report from Taiwan demonstrated potent therapeutic effect of ConA against experimental hepatoma (liver cancer); in the study by Lei and Chang,[29] ConA was found to be sequestered more by hepatic tumor cells, in preference to surrounding normal hepatocytes. Internalization of ConA occurs preferentially to the mitochondria after binding to cell membrane glycoproteins, which triggers an autophagic cell death. ConA was found to partially inhibit tumor nodule growth independent of its lymphocyte activation; the eradication of the tumor in the murine in situ hepatoma model in this study was additionally attributed to the mitogenic/lymphoproliferative action of ConA that may have activated a CD8+ T-cell-mediated, as well as NK- and NK-T cell-mediated, immune response in the liver.[29]

29.^ a b Lei HY, Chang CP (Jan 2009). "Lectin of Concanavalin A as an anti-hepatoma therapeutic agent". J Biomed Sci 16 (1): 10. doi:10.1186/1423-0127-16-10. PMC 2644972. PMID 19272170.

ナタマメ

Concanavalin A
Canavalin

ベニバナインゲン
レクチン（タンパク質） 
完熟した乾燥豆は昔から加熱調理を行わず生のままで食べると嘔吐、下痢等の消化器症状を起こすことが知られている。原因物質の一つのレクチンは、糖結合タンパク質の総称で、動物や植物に広く分布しており、植物の中でインゲン豆の仲間は特にレクチンを多く含むことが知られている。インゲン豆のレクチンは赤血球に結合して凝集させる性質があることから、赤血球凝集素とも呼ばれる。


A recent (2009) report from Taiwan demonstrated potent therapeutic effect of ConA against experimental hepatoma (liver cancer); in the study by Lei and Chang,<ref name="pmid19272170">{{cite journal |author=Lei HY, Chang CP |title=Lectin of Concanavalin A as an anti-hepatoma therapeutic agent |journal=J Biomed Sci |year=2009 |month=Jan |volume=16 |issue=1 |page=10 |pmid=19272170 |pmc=2644972 |doi=10.1186/1423-0127-16-10}}</ref> ConA was found to be sequestered more by hepatic tumor cells, in preference to surrounding normal hepatocytes. Internalization of ConA occurs preferentially to the mitochondria after binding to cell membrane glycoproteins, which triggers an autophagic cell death. ConA was found to partially inhibit tumor nodule growth independent of its lymphocyte activation; the eradication of the tumor in the murine in situ hepatoma model in this study was additionally attributed to the mitogenic/lymphoproliferative action of ConA that may have activated a CD8+ T-cell-mediated, as well as NK- and NK-T cell-mediated, immune response in the liver.<ref name="pmid19272170" />