NF-κB

NF-κB
nuclear factor kappa B
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)

Aberrant activation of NF-κB is frequently observed in many cancers. Moreover, suppression of NF-κB limits the proliferation of cancer cells. In addition, NF-κB is a key player in the inflammatory response. Hence methods of inhibiting NF-κB signaling has potential therapeutic application in cancer and inflammatory diseases.