angiogenesis inhibition by minocycline - apex @ ウィキ

angiogenesis inhibition by minocycline

Clarithromycin
erythromycin
roxithromycin
14-membered ring macrolide antibiotic
VEGF
matrix metalloproteinase inhibitors
matrix metalloproteinase inhibitors cancer therapy

metformin

Old antibiotic reduces the growth of harmful blood vessels following stroke

Inhibitory Effects of Celecoxib in Combination with Minocycline on Growth of Breast Cancer Bone Metastasis: an Experiment Study

Effect of macrolides on multiple drug resistance in human lung cancer cells
http://kaken.nii.ac.jp/d/p/13670593.ja.html
Recently it has been reported that clarithromycin (CAM), a 14-membered ring macrolide, prolongs the survival of patients with advanced lung cancer and that 14-member macrolides have immunomodulatory effects on a variety of cells including airway epithelial cells. On the basis of the above results, we hypothesized that 14-member macrolides would have some anticancer therapeutic effects. To evaluate this hypothesis, we examined the effect of macrolide antibiotics on chemotherapeutic drug-induced apoptosis of human non-small lung cancer (NSLC) cells. Tumor cells were incubated for 3 days with 14-member macrolides, CAM and erythromycin, or 16-member macrolides, josamycin and midecamycin, prior to cisplatin (CDDP) or doxorubicin treatment. Both of 14-member macrolides enhanced chemotherapeutic agent-induced apoptosis of NSLC cells carrying wild-type (wt) p53 (RERF-LC-MS, A549, EBC-1, and SQ-5) whereas 16-member macrolides did not. In p53 null NCI-H358 cells, neither anticancer agent alone nor the combination of 14-member macrolide and anticancer agent induced apoptosis.

Chemotherapeutic agents induced the cell surface Fas and Fas ligand expression in wt p53 tumor cells, and the combination of 14-member macrolide and anticancer agent enhanced this effect. Pretreatment with a vector expressing dominant-negative p53 abrogated the apoptosis of wt p53 NSLC cells induced by CAM and CDDP. Clarithromycin suppressed the function of P- glycoprotein in NSLC cells carrying wt p53. Fourteen-member macrolides increased the level of p53 in wt p53 NSLC cells. These results indicate that 14-member macrolides enhanced chemotherapeutic agent-induced apoptosis in human NSLC cells by p53-dependent fashion.

J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):308-12.

Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron.

Leyden JJ.
Abstract

Serum concentrations of tetracycline hydrochloride and minocycline hydrochloride were compared when administered with water, milk, a meal, and 300 mg ferrous sulfate in two groups of eight volunteers. Absorption of both antibiotics was significantly decreased by administration with iron (77% inhibition with minocycline and 81% with tetracycline), milk (27% inhibition with minocycline, 65% with tetracycline), and food (13% inhibition with minocycline and 46% with tetracycline). The inhibitory effect on absorption with food and milk was significantly greater for tetracycline than for minocycline.

PMID: 3838321 [PubMed - indexed for MEDLINE]

MIC にとらわれない感染症治療
－マクロライド長期治療の経験を生かして－
三笠桂一
奈良県立医科大学感染症センター