Knock-out Database - Signal Transduction シグナル伝達

目標３００ genes for database issue
Knock-Out Database

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BKT

• Mice deficient in BKT elicit X-linked immunodeficience
  • Satterthwaite AB et al 1998 Semin Immunol

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CBL-B

• CBL-B null mice have enhanced long-term memory and show an enhancement in short-term plasticity.
  • Tan DP et al 2006 Proc Natl Acad Sci U S A

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FYB

• T-cell from mice deficient in FYB show markedly impaired proliferaction.
  • Peterson EJ et al 2001 Science

Fyk

• T-cell from mice deficient in FYK exhibit a remarkably specific lymphoid defect:thymocytes are refractile to stimulation through the TCR with mitogen or antigen.
  • Appleby MW et al 1992 Cell

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ITK

• Mice deficient in ITK have reduced proliferative responses to MHC stimulation and anti-TCR cross-linking.
  • Liao XC et al 1995 Immunity

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GAB1

• Mice deficient in GAB1 die at the early phase of development with multiple defects in heart, placenta, liver, spleen and muscle development.
  • Itoh M et al 2000 Mol Cell Biol

GAB2

• no detectable defects in normal mouse development, hematopoiesis, or immune system function.
  • Sarmay G et al 2006 Immuno Lett

GAB3

• no detectable defects in normal mouse development, hematopoiesis, or immune system function.
  • Seiffert M et al 2003 Mol Cell Biol

GRAP

• Mice deficient in Grap(-/-) enhance proliferation.
  • Shen R et al 2002 Mol Cell Biol

GRAP2(GADS)

• Thymocytes deficient in GRAP2(-/-) are blocked in proliferaction during maturation of T-cell.
  • Yoder J et al 2001 Science
• B-cells deficient in GRAP2(-/-) impaire homeostatic proliferation.
  • Yankee TM et al Eur J Immunol

GRB2

• Mice deficient in GRB2 die at the early phase of development.
  • Cheng AM et al 1998 Cell

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LCK

• Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocyte population.
  • Molina et al 1992 Nature

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Rap1A

• T cells and B cells of RAP1 deficient mice impair integrin-mediated cell adhesion.
  • Duchniewicz M et al 2006 Mol Cell Biol

RasGRP1

• T cells deficient in RasGRP1 have defective proliferative responses.
• late-onset lymphoproliferation
• autoimmunity
  • Coughlin JJ et al 2006 Immunol Lett
• B cell deficient in RasGRP2 and RasGRP1 have defective proliferative responses.
  • Coughlin JJ et al 2006 Immunol Lett

RasGRP2

• B cell deficient in RasGRP2 and RasGRP1 have defective proliferative responses.
  • Coughlin JJ et al 2006 Immunol Lett
  • Coughlin JJ et al 2005 J Immunol

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SHC1, ShcA

• Mice deficient in SHC1 die at day 11.5
  • Lai KM and Pawson T 2000 Genes Dev
• Mice deficient in SHC1 fail to produce IL-2 because of impaired MAP kinase activation.
  • Iwashima M et al 2002 Proc Natl Acad Sci U S A

SOS1

• Mice deficient in SOS1 die at the early phase of development.
  • Wang DZ et al 1997 Genes Dev.

SOS2

• No detectable defects in normal mouse development, growth, and fertility.
  • Esteban LM et al 2000 Proc Natl Acad Sci U S A

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VAV1

• Mice deficient in VAV1 and VAV2 (-/-,-/-) reduce mature B cells.
  • Tedford K et al 2001 Nat Immunol
• T-cell of mice deficient in VAV1 (-/-) exhibit impaired antigen receptor signaling.
  • Fischer KD et al 1995 Nature

VAV2

• Mice deficient in VAV1 and VAV2 (-/-,-/-) reduce mature B cells.
  • Tedford K et al 2001 Nat Immunol
• B cell of mice deficient in VAV2 are defective in the ablity to switch immunoglobulin class.
  • Doody GM et al 2001 Nature

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WASP

• T-cell of mice deficient in WASP impair proliferation and antigen receptor cap formation in response to anti-CD3zeta stimulation.
  • Snapper SB et al 1998 Immunity

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3BP2

• B-cell from deficient in 3BP2 impaire proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to BCR ligation.
  • de la Fuente MA et al 2006 Mol Cell Biol