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<p>no1</p>
<br>
<p><font size="5">「Asymmetric cell
division:lessonsfromfliesandworms.」</font></p>
<br>
<p>Curr Opin Genet Dev. 1998 Aug;8(4):392-9. Review.</p>
<br>
<p>Bingwei Lu, Lily Y Jan and Yuh-Nung Jan</p>
<br>
知らない単語<br>
<br>
<!-- no1 -->
<p>
amenable【形】従順{じゅうじゅん}な、素直{すなお}な、影響{えいきょう}を受けやすい、敏感{びんかん}に反応{はんのう}する、従う義務{ぎむ}のある、責任{せきにん}を負うべき</p>
<p><br>
使われ方 <font color="red">genetically amenable systems
suchasDrosophilaandCaenorhabditis elegans</font><br></p>
<br>
<!-- no2 -->bear on<br>
~に関係{かんけい}する、~の方を指す<br>
使われ方<br>
<font color="red">progresses made during the past year that bear on
themechanismsof asymmetric cell division.</font><br>
<!-- no3 -->
<p>メモ</p>
<br>
・Introduction<br>
<p>During an asymmetric cell division, the two daughter cells
mayacquiredifferent developmental</p>
<p>potentials by the unequal seregation of cell-fate
determinants(intrinsicmechanism) or because</p>
<p>of differential influences from their surroundings
(extrinsicmechanism)[Cell1992, 68:237-255.]</p>
<br>
<p>Drosophila・・・intrinsic+extrinsic=a large number of distinct
celltypesthat are organized with</p>
<p> stereotyped spatial relationshis
toconstitutethe central nervous system(CNS) and</p>
<p> the peripheral nervous system(PNS).</p>
<p>C. elegans・・・intrinsic+extrinsic=the diverse cell types
thatconstructan embryo.</p>
<br>
<br>
<br>
Drosophila PNS development<br>
<p>external sensory(ES) organ is derived from a sensory organ precursor (SOP)
cell through two rounds of asymmetric divisions</p>
<br>
<p>原因 secified by the preferential segregation of numb gene product into
one of the daughter cells.</p>
<p>no1</p>
<br>
<p><font size="5">「Asymmetric cell division:lessons from flies
andworms.」</font></p>
<br>
<p>Curr Opin Genet Dev. 1998 Aug;8(4):392-9. Review.</p>
<br>
<p>Bingwei Lu, Lily Y Jan and Yuh-Nung Jan</p>
<br>
知らない単語<br>
<br>
<!-- no1 -->
<p>
amenable【形】従順{じゅうじゅん}な、素直{すなお}な、影響{えいきょう}を受けやすい、敏感{びんかん}に反応{はんのう}する、従う義務{ぎむ}のある、責任{せきにん}を負うべき</p>
<p><font color="#FF0000">genetically amenable systems such
as<em>Drosophila</em> and <em>Caenorhabditis elegans</em></font><br></p>
<br>
<!-- no2 -->bear
on ~に関係{かんけい}する、~の方を指す<br>
<font color="#FF0000">progresses made during the past year that bear on
themechanisms of asymmetric cell division.</font><br>
<!-- no3 --><br>
<p>メモ</p>
<br>
・Introduction<br>
<p>During an asymmetric cell division,the twodaughter cells may
acquiredifferent developmental</p>
<p>potentials by the unequal seregation of cell-fate
determinants(intrinsicmechanism) or because</p>
<p>of differential influences from their
surroundings(extrinsicmechanism)[Cell1992,68:237-255.]</p>
<br>
<p>Drosophila・・・intrinsic+extrinsic=a large number of distinct cell
typesthat are organized with</p>
<p> stereotyped spatial relationships toconstitute
the central nervous system</p>
<p> (CNS)and the peripheral
nervoussystem(PNS).</p>
<p>C.elegans・・・intrinsic+extrinsic=the diverse celltypes that constructan
embryo.</p>
<br>
<br>
<br>
Drosophila PNS development<br>
<p> external sensory(ES) organ isderived
from a sensory organ</p>
<p> precursor (SOP)
cellthrough two rounds of asymmetricdivisions</p>
<br>
<p> 原因</p>
<p> specified by
thepreferential segregation of numb gene product into</p>
<p> one of the
daughtercells.</p>
<p> Numb protein is
localized into a crescent overlaying one of the</p>
<p>
centrosomes
and is segregated preferentially into the IIb cell after</p>
<p>
division.</p>
<br>
<p>
SOP細胞と同様に、CNS細胞においてもそのdMP2/vMP2の</p>
<p>
2状態を決定するのにNumbは関与しているだろう。sibling
muscle</p>
<p>
founder cell fate decision in the myogenic lineageでも見られる。</p>
<br>
<p>
→このようにNumbタンパク質は異なる細胞系列にまたがって</p>
<p>
細胞運命を決定する役目を果たす</p>
<p> →<font color=
"#FF0000">非対称分裂の普遍的な機構なのではないか。</font></p>
<p><font color="#330033">第一パラグラフ了</font></p>
<br>
<p align="center"><img alt="fig1" src=
"http://www.geocities.jp/g050189/review1fig1.jpg"></p>
<p> </p>
<p>
<br></p>
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