CANOMAD syndrome - keisuke_goto @ ウィキ

Cold agglutinins are seen in CANOMAD syndrome (CANOMAD is an acronym for chronic ataxic neuropathy ophthalmoplegia M-protein agglutination disialosyl antibodies). CANOMAD syndrome is described by gait and upper-limb ataxia; cranial nerve involvement with external ophthalmoplegia; and the presence of cold agglutinins, IgM paraprotein, and anti-disialosyl antibodies (Delval, 2006). Both the neurologic and hematologic symptoms have been seen to respond to rituximab (Siddiqui, 2003).

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