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Chemical genomics

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2010


Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses

S Setoguchi, JM Higgins, H Mogun, VK Mootha, J … - American Heart …, 2010 - Elsevier
http://linkinghub.elsevier.com/retrieve/pii/S0002870309009624
New users of propranolol and other β-blockers (BBs) aged ≥65 were identified using data from Medicare and drug benefit programs in 2 states (1994-2005). The primary end point studied was hospitalization for myopathy or rhabdomyolysis. We used stratified Cox proportional ...

Identification of an ABCB/P-glycoprotein-specific inhibitor of auxin transport by chemical genomics

JY Kim, S Henrichs, A Bailly, V Vincenzetti, V … - Journal of Biological …, 2010 - ASBMB
http://www.jbc.org/content/early/2010/05/14/jbc.M110.105981.full.pdf
From the Laboratory of Plant Systems Bio-Dynamics, Pohang University of Science & Technology, Pohang, Republic of Korea1,University of Zurich and Zurich-Basel Plant Science Center, Institute of Plant Biology, Zurich, Switzerland2, Department of Horticulture, ...

Physcion-8-O-β-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation: Possible involvement of …

SU Lee, YH Choi, YS Kim, SJ Park, HB … - Journal of Cellular …, 2010 - interscience.wiley.com
... 1 Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea 2 Department of Biology, Chungnam National University, Daejeon 305-765, Korea 3 Laboratory of Phytochemistry Research, Korea Research Institute of Chemical ...

Preparation and characterization of monodisperse CdS quantum dot-polymer microspheres

Q Shao, C Yang, L Jiang, J He, S … - Journal of Polymer …, 2010 - interscience.wiley.com
... 1 Nano-Micro Materials Research Center, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China 2 Shenzhen Key Laboratory of Special Functional Materials, Shenzhen ...

Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation

ML Sos, HB Rode, S Heynck, M Peifer, F Fischer, S … - Cancer Research, 2010 - AACR
... Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, 2 Center of Integrated Oncology and Department I of Internal Medicine, University of Köln, Cologne, Germany; 3 Chemical Genomics Centre of the Max ...

Inside Cover: A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety (ChemMedChem 5/2010)

MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com
... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax:(+1) 301-217-5736. email: Craig J. Thomas ([email protected]). ...

A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com
... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax:(+1) 301-217-5736. email: Craig J. Thomas ([email protected]). ...

A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor

S Neumann, W Huang, E Eliseeva, S Titus, CJ … - Endocrinology, 2010 - Endocrine Soc
... Clinical Endocrinology Branch (SN, EE, MCG), National Institute of Diabetes and Digestive and Kidney Diseases, and National Institutes of Health (NIH) Chemical Genomics Center (WH, ST, CJT), National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 ...

Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx

S Terry, C Austin, J Inglese, D Meeker, … - Assay and drug …, 2010 - liebertonline.com
... Christopher Austin NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. James Inglese NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. ...

A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana

M Serrano, DA Hubert, JL Dangl, P Schulze-Lefert, E … - Planta, 2010 - Springer
Page 1. ORIGINAL ARTICLE A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana Mario Serrano • David A. Hubert • Jeffery L. Dangl • Paul Schulze-Lefert • Erich Kombrink ...

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最終更新:2010年05月28日 21:53