- visitors
2010/5/31
PKS and NRPS release mechanisms
... Review. Nat. Prod. Rep., 2010, 27, 255 - 278, DOI: 10.1039/b912037h. PKS and NRPS release mechanisms Liangcheng Du and Lili Lou. Covering: up to September 2009. ...
Antimicrobial natural products: an update on future antibiotic drug candidates
... Review. Nat. Prod. Rep., 2010, 27, 238 - 254, DOI: 10.1039/b916096e. Antimicrobial natural products: an update on future antibiotic drug candidates Muhammad Saleem, Mamona Nazir, Muhammad Shaiq Ali, Hidayat Hussain, Yong Sup Lee, Naheed Riaz and Abdul Jabbar. ...
Branch-and-Bound Algorithms for Enumerating Treelike Chemical Graphs with Given Path Frequency Using Detachment-Cut
Computational methods of enumerating chemical graphs have attained great importance in chemoinformatics since they lead to a variety of useful applications including structure determination of novel chemical compounds. Recently, Fujiwara et al. have presented an efficient branch-and-bound ...
A Semantic Web Ontology for Small Molecules and Their Biological Targets
A wide range of data on sequences, structures, pathways, and networks of genes and gene products is available for hypothesis testing and discovery in biological and biomedical research. However, data describing the physical, chemical, and biological properties of small ...
Drug-and Lead-likeness, Target Class, and Molecular Diversity Analysis of 7.9 Million Commercially Available Organic Compounds Provided by 29 Suppliers
A database of 7.9 million compounds commercially available from 29 suppliers in 2008−2009 was assembled and analyzed. 5.2 million structures of this database were identified to be unique and were subjected to an assessment of physical and biological properties and ...
Computationally Efficient Algorithm to Identify Matched Molecular Pairs (MMPs) in Large Data Sets
Modern drug discovery organizations generate large volumes of SAR data. A promising methodology that can be used to mine this chemical data to identify novel structure−activity relationships is the matched molecular pair (MMP) methodology. However, before the full potential of the ...
Construction of Functional Group Reactivity Database under Various Reaction Conditions Automatically Extracted from Reaction Database in a Synthesis Design …
To be able to estimate the reactivity of functional groups under certain reaction conditions, we have stored three types of data: (1) data of change or destruction of the functional groups by the conditions of the reaction conditions; (2) data showing no influence of the reaction ...
Prokaryotic Ubiquitin-Like Protein Provides a Two-Part Degron to Mycobacterium Proteasome Substrates
Prokaryotic ubiquitin-like protein (Pup) is a post-translational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino-terminus of Pup is required for degradation while the
Phylogeny of Gammaproteobacteria
KP Williams, JJ Gillespie, BWS Sobral, EK … - Journal of …, 2010 - Am Soc Microbiol
The phylogeny of the large bacterial class Gammaproteobacteria has been difficult to resolve. Here we apply a telescoping multi-protein approach to the problem for 104 diverse gammaproteobacterial genomes, based on a set of 356 protein families for the whole class, and even larger sets for each of four cohesive subregions of the tree.
A role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine
SG Kozmin, J Wang, RM Schaaper - Journal of Bacteriology, 2010 - Am Soc Microbiol
Page 1. A role for CysJ flavin reductase in molybdenum cofactor- 1 dependent resistance of Escherichia coli to 6-N- 2 hydroxylaminopurine 3 4 Stanislav G. Kozmin, Jian Wang, and Roel M. Schaaper* 5 6 Laboratory of Molecular ...
Open source bioimage informatics for cell biology
JR Swedlow, KW Eliceiri - Trends in cell biology, 2009 - Elsevier
Significant technical advances in imaging, molecular biology and genomics have fueled a revolution in cell biology, in that the molecular and structural processes of the cell are now visualized and measured routinely. Driving much of this recent development has been the advent of ...
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
J Schellenberger, JO Park, TM Conrad, BØ … - BMC …, 2010 - biomedcentral.com
BiGG currently contains 7 reconstructions including two versions of E. coli. There are a total of 7234 unique reactions and exchanges in the database. Exchange reactions carry metabolites from the extracellular 'compartment' across the system boundary and are not technically part of the metabolic reconstruction. Translocation reactions carry a metabolite between compartments
2010/5/24
Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite
RD Schulte, C Makus, B Hasert, NK … - Proceedings of the …, 2010 - National Acad Sciences
The coevolution between hosts and parasites is predicted to have complex evolutionary consequences for both antagonists, often within short time periods. To date, conclusive experimental support for the predictions is available mainly for microbial host systems, but for only a few ...
Genomic arrangement of bacterial operons is constrained by biological pathways encoded in the genome
Y Yin, H Zhang, V Olman, Y Xu - … of the National Academy of Sciences, 2010 - link.aip.org
It is generally known that bacterial genes working in the same biological pathways tend to group into operons, possibly to facilitate cotranscription and to provide stoichiometry. However, very little is understood about what may determine the global arrangement of bacterial genes ...
Revealing strengths and weaknesses of methods for gene network inference
D Marbach, RJ Prill, T Schaffter, C … - Proceedings of the …, 2010 - National Acad Sciences
Numerous methods have been developed for inferring gene regulatory networks from expression data, however, both their absolute and comparative performance remain poorly understood. In this paper, we introduce a framework for critical performance assessment of methods ...
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis
… , JW Labonte, AG Newman, J Wong, … - Proceedings of the …, 2010 - National Acad Sciences
Polyketide natural products possess diverse architectures and biological functions and share a subset of biosynthetic steps with fatty acid synthesis. The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is most often carried out by a ...
How the Sequence of a Gene Can Tune Its Translation
K Fredrick, M Ibba - Cell, 2010 - Elsevier
Just about every molecular biologist, intentionally or not, has conducted experiments on the roles of codon usage during translation. For example, to prepare a protein of interest, a foreign gene might be expressed in a heterologous host like the bacterium Escherichia coli, but ...
An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation
T Tuller, A Carmi, K Vestsigian, S Navon, Y Dorfan, J … - Cell, 2010 - Elsevier
Recent years have seen intensive progress in measuring protein translation. However, the contributions of coding sequences to the efficiency of the process remain unclear. Here, we identify a universally conserved profile of translation efficiency along mRNAs computed based on adaptation ...
The Chemical MUPpeteer
I Rodriguez - Cell, 2010 - Elsevier
To face a hostile world, animals have developed a complex array of sensory systems. In vertebrates, this sensory toolbox provides such a keen selective advantage that a considerable fraction of the vertebrate genome is devoted to its development and function. The primary ...
Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck
Y Lee, X Yang, Y Huang, H Fan, Q Zhang… - 2010 - papers.gersteinlab.org
Due to the large number of putative microRNA gene targets predicted by sequence-alignment databases and the relative low accuracy of such predictions which are conducted independently of biological context by design, systematic experimental
Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions
SL Martinez, RD Kolodner - Proceedings of the National …, 2010 - National Acad Sciences
Many of the mutations reported as potentially causing Lynch syndrome are missense mutations in human mismatch repair (MMR) genes. Here, we used a Saccharomyces cerevisiae-based system to study polymorphisms and suspected missense mutations in human MMR ...
最終更新：2010年05月31日 16:53
