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Metabolic pathway analysis of enzyme-deficient human red blood cells
Five enzymopathies (G6PDH, TPI, PGI, DPGM and PGK deficiencies) in the human red blood cells are investigated using a stoichiometric modeling approach, ie, metabolic pathway analysis. Elementary flux modes (EFMs) corresponding to each enzyme deficiency case ...
Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms
Page 1. BIOINFORMATICS Vol. 19 no. 2 2003 Pages 270–277 Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms Hongwu Ma1, 2 and An-Ping Zeng1,∗ 1GBF ...
Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism
Abstract Elementary mode analysis is a useful metabolic pathway analysis tool to identify the structure of a metabolic network that links the cellular phenotype to the corresponding genotype. The analysis can decompose the intricate metabolic network comprised of ...
Extreme pathway analysis of human red blood cell metabolism
Constraints-based models: regulation of gene expression reduces the steady-state solution space
... Biol. 203, 249, 283. 26. CH SCHILLING, S. SCHUSTER, BO PALSSON and R.HEINRICH, Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15 (1999), pp. 296–303. ...
The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis
From genome to cellular phenotype—a role for metabolic flux analysis?
... whether a bypass exists within a complex network. Metabolic pathway analysis aims to identify indispensable enzymes, thus predicting the effects of their deletion or inhibition. Flux analysis should also allow the determination ...
On-line metabolic pathway analysis based on metabolic signal flow diagram
Abstract: In this work, an integrated modeling approach based on a metabolic signal flow diagram and cellular energetics was used to model the metabolic pathway analysis for the cultivation of yeast on glucose. This ap- proach enables us to make a clear analysis of the flow ...
Metabolic pathway analysis of recombinant Saccharomyces cerevisiae with a galactose-inducible promoter based on a signal flow modeling approach
The objective of this work was to develop a signal flow diagram-based modeling approach proposed by Endo et al. (1976) to organize the network of complex metabolic reactions occurring in the living cell, employing directed signal flow diagram in which the enzyme reaction ...
Energy balance for analysis of complex metabolic networks
最終更新：2010年09月28日 21:22
