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Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems
... dimensional space. From metabolic pathway analysis, the edges of the high-dimensional flux cone are vectors that correspond to sys- temically defined “extreme pathways” spanning the ca- pabilities of the system. The addition ...
Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks
Abstract: Central carbon metabolism of the yeast Saccha- romyces cerevisiae was analyzed using metabolic pathway analysis tools. Elementary flux modes for three substrates (glucose, galactose, and ethanol) were determined using the catabolic reactions ...
Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum
Metabolic pathway analysis was carried out to predict the metabolic potential of Corynebacterium glutamicum and Escherichia coli for the production of L-methionine. Based on detailed stoichiometric models for these organisms, this allowed the calculation of the theoretically optimal ...
The genome-scale metabolic extreme pathway structure in Haemophilus influenzae shows significant network redundancy
... 229–248. Abstract | PDF (428 K) | View Record in Scopus | Cited By in Scopus (198). 19. CHSCHILLING, S. SCHUSTER, BO PALSSON and R. HEINRICH, Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. ...
Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis
The emergence of multidrug resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. We have performed an insilico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen M. tuberculosis. Enzymes from the ...
In silico metabolic pathway analysis and design: succinic acid production by metabolically engineered Escherichia coli as an example
Abstract The intracellular metabolic fluxes can be calculated by metabolic flux analysis, which uses a stoichiometric model for the intracellular reactions along with mass balances around the intra- cellular metabolites. In this study, we have constructed in silico metabolic pathway ...
Determination of redundancy and systems properties of the metabolic network of Helicobacter pylori using genome-scale extreme pathway analysis
Metabolic pathway analysis in trypanosomes and malaria parasites.
Identification of novel drug targets is required for the development of new classes of drugs to overcome drug resistance and replace less efficacious treatments. In theory, knowledge of the entire genome of a pathogen identifies every potential drug target in any given microbe. ...
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks
... Trends Biotechnol. 17, 53–60(1999). | Article | PubMed | ISI | ChemPort |; Schilling, CH, Schuster, S., Palsson, BO & Heinrich R. Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15, 296–303 (1999). ...
最終更新：2010年09月28日 21:31
